Krairittichai Udom, Chittaganpitch Malinee
Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.
J Med Assoc Thai. 2013 Mar;96 Suppl 3:S1-7.
To evaluate the immune response to trivalent influenza vaccination in Thai patients with hemodialysis (HD) or kidney transplant (KT) compared with healthy volunteers.
This was a cross-sectional study in Thai healthy volunteers and patients with HD and KT who received the trivalent influenza vaccine provided by the Ministry of Public Health of Thailand from 1 November 2011 to 31 December 2011. Each subject was injected intramuscularly with one dose (0.5 milliliter) of trivalent influenza vaccine containing viral strains recommended by the WHO for the 2011 influenza season (southern hemisphere). Blood samples before and 6 weeks after the vaccination were measured for immune response using a hemagglutination-inhibition antibody assay.
Subjects consisted of 30 healthy volunteers, 30 patients with HD and 30 patients with KT Prevalence of pre-vaccination seroprotective (SP) immunity in each group (healthy volunteers, HD, KT) was as follows: against H1N1 (33.3%: 23.3%: 10.0%), H3N2 (80.0%: 26.7%: 23.3%) and B (60.0%: 20.0%: 3.30%) viral strains, respectively. Those who were seronegative (SN) before testing positive after one dose of this vaccine were as follows: H1N1 (100.0%: 73.9%: 74.1%), H3N2 (66.7%: 86.4%: 34.8%) or B (58.3%: 66. 7%: 48.3%) viral strains, respectively. The healthy group showed significantly higher SP immune response for H1N1 than the HD and KT groups (p = 0.023). The HD group had significantly higher SP immune response for H3N2 than the KT groups (p = 0.001). Immune responses for the B vaccine in all groups were not different. No major adverse event was found in any group.
Immune response for H1N1 vaccine in the HD and KT groups was slightly less than that of the healthy group. Immune response for H3N2 vaccine in the KT groups was less than in the healthy and HD groups. Immune responses for B vaccine in all groups were not different.
评估泰国血液透析（HD）患者或肾移植（KT）患者与健康志愿者相比，对三价流感疫苗的免疫反应。
这是一项横断面研究，研究对象为泰国健康志愿者以及接受泰国公共卫生部于2011年11月1日至2011年12月31日提供的三价流感疫苗的HD患者和KT患者。每位受试者肌肉注射一剂（0.5毫升）含有世界卫生组织推荐的2011年流感季节（南半球）病毒株的三价流感疫苗。使用血凝抑制抗体检测法测量接种疫苗前和接种后6周的血液样本的免疫反应。
受试者包括30名健康志愿者、30名HD患者和30名KT患者。每组（健康志愿者、HD患者、KT患者）接种疫苗前血清保护性（SP）免疫的患病率如下：针对H1N1病毒株（33.3%: 23.3%: 10.0%）、H3N2病毒株（80.0%: 26.7%: 23.3%）和B病毒株（60.0%: 20.0%: 3.30%）。接种一剂该疫苗后检测呈阳性的血清阴性（SN）者如下：针对H1N1病毒株（100.0%: 73.9%: 74.1%）、H3N2病毒株（66.7%: 86.4%: 34.8%）或B病毒株（58.3%: 66.7%: 48.3%）。健康组对H1N1的SP免疫反应显著高于HD组和KT组（p = 0.023）。HD组对H3N2的SP免疫反应显著高于KT组（p = 0.001）。所有组对B疫苗的免疫反应无差异。任何组均未发现重大不良事件。
HD组和KT组对H1N1疫苗的免疫反应略低于健康组。KT组对H3N2疫苗的免疫反应低于健康组和HD组。所有组对B疫苗的免疫反应无差异。
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