Tantivesruangdet Nopmanee
Department of Emergency, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.
J Med Assoc Thai. 2013 Mar;96 Suppl 3:S64-8.
The stability and quality of Adrenaline medications were advocated 2 to be stored in temperature labeled at 2 degrees C to 8 degrees C at drug storage room. Thailand is located in a tropical area with the average room temperature within 25 degrees C. There was no previous study of adrenaline medication stability and quality in Thailand.
To assess the stability and quality of Adrenaline stored at room temperature in Ambulance and drug storage room of Narenthorn center, Rajavithi Hospital.
Forty vials of Adrenaline Bitartrade were stored at the temperature in each season for a period of 4 weeks. Half were stored in one Ambulance and the other half in a drug storage room. Samples were then analyzed for their appearance, pH and using stability indicating High Performance Liquid Chromatography (HPLC).
The average temperature in the drug storage rooms were 30 degrees C, 28 degrees C and 27 degrees C in hot, rainy and cool seasons respectively; and 34 degrees C, 32 degrees C and 31 degrees C in Narenthorn Ambulance. The appearance of adrenaline was not changed as it was still clear. The average pH is 3.18 to 3.36. Adrenaline was found to be stable when storage in both ambulance and drug storage room. The percent drug remaining was 90 Ia% to 115 Ia%. There was no significant difference in between drug quality the two storage places (p = 0.792). No significant difference was found in the percent drug remaining between the hot and cool season. There was significant difference in the percent drug remaining between the rainy season from other seasons (p < 0.005).
Even though the temperature in the drug storage room and Ambulance was higher than recommended storage temperature, adrenaline stability and quality were not changed when testing by HPLC.
肾上腺素药物的稳定性和质量要求在药品储存室中储存于2℃至8℃的温度环境下。泰国位于热带地区，室内平均温度在25℃以内。此前泰国尚未有关于肾上腺素药物稳定性和质量的研究。
评估肾上腺素在拉贾维蒂医院纳伦通中心救护车和药品储存室室温下的稳定性和质量。
40瓶重酒石酸肾上腺素在每个季节的温度下储存4周。一半储存在一辆救护车中，另一半储存在药品储存室。然后对样品进行外观、pH值分析，并使用稳定性指示高效液相色谱法（HPLC）进行分析。
药品储存室在炎热、雨季和凉爽季节的平均温度分别为30℃、28℃和27℃；在纳伦通救护车中的平均温度分别为34℃、32℃和31℃。肾上腺素的外观未发生变化，仍保持清澈。平均pH值为3.18至3.36。发现在救护车和药品储存室中储存时肾上腺素均稳定。药物残留百分比为90 Ia%至115 Ia%。两个储存地点的药品质量之间无显著差异（p = 0.792）。炎热季节和凉爽季节之间的药物残留百分比无显著差异。雨季与其他季节之间的药物残留百分比存在显著差异（p < 0.005）。
尽管药品储存室和救护车中的温度高于推荐储存温度，但通过HPLC测试时，肾上腺素的稳定性和质量并未改变。
