Faculty of Education and Psychology, University of Tabriz, Tabriz 5166614776, Iran.
Alcohol. 2013 Jun;47(4):309-16. doi: 10.1016/j.alcohol.2013.01.008.
Chronic ethanol consumption is often accompanied by numerous cognitive deficits and may lead to long-lasting impairments in spatial learning and memory. The aim of the present study was to evaluate the therapeutic potential of regular treadmill exercise on hippocampal-dependent memory in ethanol-treated rats. Spatial memory was tested in a Morris Water Maze task. Adult male Wistar rats were exposed to ethanol (4 g/kg, 20% v/v for 4 weeks) and effects of three exercise protocols (pre-ethanol, post-ethanol and pre-to-post-ethanol treatment) were examined. Results showed that ethanol exposure resulted in longer escape latencies during the acquisition phase of the Morris Water Maze task. Moreover, all three exercise protocols significantly decreased the latency to locate the hidden platform. During the probe trial, ethanol led to decreased time spent in the target quadrant. In contrast, performance on the probe trial was significantly better in the rats that had done the post- and pre-to-post-ethanol, but not pre-ethanol, exercises. These findings suggest that treadmill running can attenuate the adverse effects of chronic ethanol exposure on spatial memory, and may serve as a non-pharmacological alcohol abuse treatment.
慢性乙醇摄入常伴有多种认知功能缺陷，并可能导致空间学习和记忆的长期损害。本研究旨在评估常规跑步机运动对乙醇处理大鼠海马依赖性记忆的治疗潜力。在 Morris 水迷宫任务中测试空间记忆。雄性 Wistar 大鼠接受乙醇（4 g/kg，20% v/v ，4 周）处理，并检测三种运动方案（乙醇前、乙醇后和乙醇前至后处理）的效果。结果表明，乙醇暴露导致 Morris 水迷宫任务获得阶段的逃避潜伏期延长。此外，所有三种运动方案均显著降低了寻找隐藏平台的潜伏期。在探测试验中，乙醇导致在目标象限中花费的时间减少。相比之下，进行后乙醇和乙醇前至后处理的大鼠在探测试验中的表现明显更好，而进行乙醇前处理的大鼠则不然。这些发现表明，跑步机跑步可以减轻慢性乙醇暴露对空间记忆的不良影响，并且可能作为一种非药物滥用治疗方法。
