Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Int J Infect Dis. 2013 Nov;17(11):e1060-1. doi: 10.1016/j.ijid.2013.03.008. Epub 2013 May 16.
The purpose of this study was to investigate the penetration of linezolid into the mediastinum and pleural space by comparing its concentration in the serum, mediastinum, and pleural space. The linezolid area under the concentration-versus-time curve from zero to 12h (AUC)(mediastinum fluid/serum) and AUC(pleural fluid/serum) ratio were 1.32 and 1.64, respectively. The results suggest that the linezolid concentration in the mediastinum varies as in the serum, and that the concentration in the mediastinum is the same as or greater than that in the serum.
本研究旨在通过比较利奈唑胺在血清、纵隔和胸腔液中的浓度，来研究利奈唑胺在纵隔和胸腔中的渗透情况。利奈唑胺在 0 至 12 小时的浓度-时间曲线下面积（纵隔液/血清）和 AUC（胸腔液/血清）比值分别为 1.32 和 1.64。结果表明，纵隔中的利奈唑胺浓度与血清中的浓度相似，且纵隔中的浓度与或高于血清中的浓度。
