Amente Stefano, Lania Luigi, Majello Barbara
Department of Biology, University of Naples 'Federico II', Naples, Italy.
Biochim Biophys Acta. 2013 Oct;1829(10):981-6. doi: 10.1016/j.bbagrm.2013.05.002. Epub 2013 May 16.
DNA and histone chromatin modifying enzymes play a crucial role in chromatin remodeling in several biological processes. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is a relevant player in the regulation of a broad spectrum of biological processes including development, cellular differentiation, embryonic pluripotency and cancer. Here, we review recent insights on the role of LSD1 activity in chromatin regulatory complexes, its functional role in the epigenetic changes during embryonic development, in the establishment and maintenance of stemness and during cancer progression.
DNA和组蛋白染色质修饰酶在多个生物学过程的染色质重塑中发挥着关键作用。赖氨酸特异性去甲基化酶1（LSD1）是首个被鉴定出的组蛋白去甲基化酶，在包括发育、细胞分化、胚胎多能性和癌症在内的广泛生物学过程的调控中发挥着重要作用。在此，我们综述了关于LSD1活性在染色质调节复合物中的作用、其在胚胎发育过程中的表观遗传变化、干性的建立和维持以及癌症进展过程中的功能作用的最新见解。
