Departments of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
Section of Hematology-Medical Oncology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA 02118, USA.
Genes (Basel). 2024 Apr 27;15(5):563. doi: 10.3390/genes15050563.
TR2 and TR4 (NR2C1 and NR2C2, respectively) are evolutionarily conserved nuclear orphan receptors capable of binding direct repeat sequences in a stage-specific manner. Like other nuclear receptors, TR2 and TR4 possess important roles in transcriptional activation or repression with developmental stage and tissue specificity. TR2 and TR4 bind DNA and possess the ability to complex with available cofactors mediating developmental stage-specific actions in primitive and definitive erythrocytes. In erythropoiesis, TR2 and TR4 are required for erythroid development, maturation, and key erythroid transcription factor regulation. TR2 and TR4 recruit and interact with transcriptional corepressors or coactivators to elicit developmental stage-specific gene regulation during hematopoiesis.
TR2 和 TR4（分别为 NR2C1 和 NR2C2）是进化上保守的核孤儿受体，能够以阶段特异性的方式结合直接重复序列。与其他核受体一样，TR2 和 TR4 在转录激活或抑制方面具有重要作用，具有发育阶段和组织特异性。TR2 和 TR4 结合 DNA，并具有与现有共因子形成复合物的能力，从而介导原始和确定性红细胞中的发育阶段特异性作用。在红细胞生成中，TR2 和 TR4 是红细胞发育、成熟和关键红细胞转录因子调节所必需的。TR2 和 TR4 募集并与转录共抑制因子或共激活因子相互作用，在造血过程中引发发育阶段特异性基因调节。
