Process Chemistry and Technology Department, Central Institute of Medicinal and Aromatic Plants (CIMAP), Council of Scientific and Industrial Research (CSIR), Lucknow, India.
Fitoterapia. 2013 Sep;89:86-125. doi: 10.1016/j.fitote.2013.05.010. Epub 2013 May 17.
The diversity present in biological activities and the medicinal significance of natural products provide a renewed interest in the use of natural compounds and, more importantly, their role as a basis for drug development. Advancements in the field of natural product chemistry provide valuable information on Garcinia fruits which revealed the presence of biologically important secondary metabolites named as polyisoprenylated benzophenones (PIBs). They are mainly present in the genus Garcinia (Guttiferae) which occupies a prominent position in the history of natural products. Compared to the long history of medicinal uses and widespread research on Garcinia, the study of polyisoprenylated benzophenones was relatively limited. During recent years, these PIBs have been recognized as interesting and valuable biologically active secondary metabolites as many of the isolated polyisoprenylated benzophenones exhibited significant cytotoxic activity in in vitro and in vivo assay. During past decades, some promising advances had been achieved in understanding the chemistry and pharmacology of polyisoprenylated benzophenones. However, there has been not any systematic review on the ethnobotanical importance, chemistry, isolation techniques, structure activity relationships and the biological activities of polyisoprenylated benzophenones. In this review, the biological activity of different structures of polyisoprenylated benzophenones isolated from genus Clusia, Garcinia, Vismia, Allanblackia, Moronobea, Symphonia, Hypericum, Tovomita, Tovomiptosis and Ochrocarpus have been described. Therefore, the goal of this review article would be a valuable reference for the natural product chemists and biologists working on these PIBs. Furthermore, the review article on polyisoprenylated benzophenones would also be useful from the drug discovery point of view as cytotoxic agents in near future. This review focuses our understanding about the specific biological effects of Garcinia fruits, which may be useful for predicting other medicinal uses, potential drug or food interactions and may benefit people where the fruits are prevalent and healthcare resources are scarce.
生物活性的多样性和天然产物的药用意义为天然化合物的应用提供了新的兴趣，更重要的是，为其作为药物开发的基础提供了新的兴趣。天然产物化学领域的进展为藤黄属水果提供了有价值的信息，揭示了存在具有生物重要性的次生代谢产物，称为多异戊二烯基二苯甲酮（PIBs）。它们主要存在于藤黄属（藤黄科）中，该属在天然产物的历史上占有突出地位。与藤黄的药用历史悠久和广泛研究相比，多异戊二烯基二苯甲酮的研究相对有限。近年来，这些 PIB 已被认为是具有有趣和有价值的生物活性次生代谢产物，因为许多分离的多异戊二烯基二苯甲酮在体外和体内试验中表现出显著的细胞毒性活性。在过去的几十年中，在理解多异戊二烯基二苯甲酮的化学和药理学方面取得了一些有希望的进展。然而，对于多异戊二烯基二苯甲酮的民族植物学重要性、化学、分离技术、结构活性关系和生物活性，还没有进行任何系统的综述。在这篇综述中，描述了从藤黄属、藤黄属、卫矛属、艾伦布赖特氏菌属、莫罗诺贝氏菌属、辛普森氏菌属、贯叶连翘属、托沃米塔氏菌属、托沃米皮托西斯氏菌属和奥克罗卡帕斯属中分离出的不同结构的多异戊二烯基二苯甲酮的生物活性。因此，本文综述为从事这些 PIBs 研究的天然产物化学家提供了有价值的参考。此外，从药物发现的角度来看，关于多异戊二烯基二苯甲酮的综述文章也将非常有用，因为它可能成为未来的细胞毒性药物。本文综述重点介绍了藤黄属水果的特定生物学效应的理解，这可能有助于预测其他药用用途、潜在的药物或食物相互作用，并可能使水果流行且医疗资源稀缺的地区的人们受益。
