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吸烟及各种避孕方法在宫颈癌及其癌前病变发展过程中的作用是什么?

[What is the role of cigarette smoking and various methods of contraception in the development of cervix cancer and its precancerous conditions?].

作者信息

Barten G

机构信息

Klinik für Gynäkologie und Geburtshilfe, Bereichs Medizin der Wilhelm-Pieck-Universität Rostock.

出版信息

Zentralbl Gynakol. 1990;112(7):437-43.

PMID:2368529
Abstract

Basis of this trial are examinations of 100 patients with colposcopic and/or cytologic suspicion for precancerous or early stages of cancer of the uterine cervix and of 100 patients in the same age with normal cervical findings. The meaning discussed in literature about cigarette smoking as cofactor for developing cervical cancer and its prestages can be confirmed by our results. The portion of smoking patients with 74 per cent in the cervical groups was higher than in control group (42 per cent). Three times so much patients of the cervical group than in the controls smoked 20 cigarettes per day or more. More than 20 years smoking patients could be found only in the cervical group. 97 patients of the cervical group compared with 55 of the controls had been in the pill. Patients with cervical lesions on the average had been 3 years younger starting with hormonal contraception than the controls. The portion of pill users more than 10 years had been twice frequent in cervical group. The use of condoms was significantly more frequent in the control groups than in the cervical one (22/6). Therefore condoms are to be preferred be cause of protection against sexual transmitted diseases and indirectly cervical carcinom.

摘要

该试验的基础是对100例经阴道镜检查和/或细胞学检查怀疑患有宫颈癌癌前病变或早期癌症的患者以及100例年龄相同、宫颈检查结果正常的患者进行检查。我们的结果可以证实文献中所讨论的吸烟作为宫颈癌及其癌前阶段发展的辅助因素的意义。宫颈组吸烟患者的比例为74%,高于对照组(42%)。宫颈组每天吸20支或更多香烟的患者是对照组的三倍。仅在宫颈组中发现了吸烟超过20年的患者。宫颈组97例患者与对照组55例患者曾服用过避孕药。宫颈病变患者开始使用激素避孕的平均年龄比对照组小3岁。宫颈组中使用避孕药超过10年的比例是对照组的两倍。对照组使用避孕套的频率明显高于宫颈组(22/6)。因此,由于避孕套能预防性传播疾病并间接预防宫颈癌,所以更应优先选用。

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