Bornemann-Cimenti H, Kobald S K, Szilagyi I S, Sandner-Kiesling A
Universitätsklinik für Anästhesiologie und Intensivmedizin, Medizinische Universität Graz, Auenbruggerplatz 29, 8036, Graz, Österreich.
Schmerz. 2013 Jun;27(3):253-62. doi: 10.1007/s00482-013-1318-x.
The pain provoked by mucositis is often described as the most excruciating symptom of cancer treatment. It often causes reduced ingestion, malnutrition, and sometimes postponement or withdrawal of the therapy. For health care providers, adequate pain treatment is a major challenge. The aim of this article is to present an overview of studies on the topical treatment of mucositis pain.
A systematic search was performed in PubMed with the keywords "mucositis" "pain" and "topical" or "local". In addition, reference lists and relevant websites were scanned for appropriate literature.
A total of 47 articles were included. There is only scarce evidence for the topical treatment of mucositis pain. The most convincing studies tested opioids, corticoids and benzydamine. For the other substances, too few studies were performed, the results were contradictory, or the study quality was low.
Based on the information gathered in this systematic search of the literature, topical treatment of mucositis pain today is based on empiricism and not on scientific evidence.
口腔黏膜炎引发的疼痛常被描述为癌症治疗中最难以忍受的症状。它常导致摄入减少、营养不良，有时还会使治疗推迟或中断。对医护人员而言，充分的疼痛治疗是一项重大挑战。本文旨在概述有关口腔黏膜炎疼痛局部治疗的研究。
在PubMed中使用关键词“口腔黏膜炎”“疼痛”和“局部”或“局部的”进行系统检索。此外，还查阅了参考文献列表和相关网站以获取合适的文献。
共纳入47篇文章。关于口腔黏膜炎疼痛局部治疗的证据稀少。最具说服力的研究测试了阿片类药物、皮质类固醇和苄达明。对于其他物质，进行的研究过少，结果相互矛盾，或研究质量较低。
基于本次对文献的系统检索所收集的信息，目前口腔黏膜炎疼痛的局部治疗基于经验而非科学证据。
