Kvinnsland I, Heyeraas K J
Department of Cariology and Endodontics, School of Dentistry, University of Bergen, Norway.
Acta Odontol Scand. 1990 Jun;48(3):203-15. doi: 10.3109/00016359009005876.
The cellular dynamic pattern of pulpal healing 4, 10, 30, and 60 days after replantation of 47 apicoectomized cat incisors was studied after pulse labeling with 3H-thymidine and 35S-sulfate, autoradiography, and routine histology. In the control teeth the labeling index was less than 0.05%. The apical pulpal cells were capable of ground substance formation and cell proliferation already 4 days after replantation, with a labeling index of 7%, which increased up to 43% within 10 days. A gradual postoperative restitution and reorganization within the pulpal cellular compartment was seen. The maximum cell density, reached after 30 days, was reduced to on average 60% compared with the controls. The tissue reorganization was near completion within all pulpal zones after 60 days, and the labeling index was reduced to 2.5%. In some instances internal resorption in cervical pulpal areas negatively influenced the favorable healing. The present study shows that the pulpal healing in replanted teeth follows a consistent basic pattern in cellular dynamics and in histologic changes. The replanted tooth thus seems to be a suitable model for studies of healing and repair in connective tissues.
用³H-胸腺嘧啶核苷和³⁵S-硫酸盐进行脉冲标记、放射自显影以及常规组织学检查后，研究了47颗根尖切除的猫切牙再植后4天、10天、30天和60天牙髓愈合的细胞动态模式。在对照牙中，标记指数小于0.05%。再植后4天，根尖牙髓细胞就能够形成基质并进行细胞增殖，标记指数为7%，10天内增至43%。牙髓细胞区可见术后逐渐的恢复和重组。30天后达到的最大细胞密度与对照相比平均降低至60%。60天后所有牙髓区的组织重组接近完成，标记指数降至2.5%。在某些情况下，牙髓颈部区域的内吸收对良好愈合产生负面影响。本研究表明，再植牙的牙髓愈合在细胞动力学和组织学变化方面遵循一致的基本模式。因此，再植牙似乎是研究结缔组织愈合和修复的合适模型。
