Department of Infectious Disease, King's College London School of Medicine, London, UK.
Curr Top Microbiol Immunol. 2013;371:67-104. doi: 10.1007/978-3-642-37765-5_3.
Tetherin (BST2/CD317) has emerged as a key host cell defense molecule, inhibiting the release and spread of diverse enveloped virions from infected cells. In this chapter, I review the molecular and cellular basis for tetherin's antiviral activities and the function of virally encoded countermeasures that disrupt its function. I further describe recent advances in our understanding of tetherin's associated role in viral pattern recognition and the evidence for its role in limiting viral pathogenesis in vivo.
tetherin（BST2/CD317）已成为一种关键的宿主细胞防御分子，抑制受感染细胞中多种包膜病毒的释放和传播。在本章中，我回顾了 tetherin 抗病毒活性的分子和细胞基础，以及病毒编码的对策破坏其功能的功能。我进一步描述了我们对 tetherin 相关的病毒模式识别作用及其在限制病毒发病机制中的作用的理解的最新进展。
