Xu Jia, Lu Xiao-Jie, Wang Dan, Wu Ming-Can, Chen Shi-Jie, Li Jun-Chuan, Wang Peng
Department of Neurosurgery, Neuroscience Center, Nanjing Medical University, Affiliated Wuxi No. 2 Hospital, Wuxi 214002, Jiangsu Province, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2013 Feb;25(1):28-30.
To establish an experimental model of neuroschistosomiasis and investigate the model establishment factors.
Rabbits were used for the animal model and Schistosoma japonicum eggs (1 mg/ml) were directly injected into the brain by two ways of a bone drill or needle. The symptoms were observed and in the first and second week and later, the rabbits' brains were removed for pathological examinations.
One to two weeks after the injection of schistosome eggs, the rabbits had various neurological symptoms such as loss of appetite, hemiparesis, seizure, etc. The pathological analysis showed the schistosome egg granuloma inflammatory reaction among 90% rabbits.
This new method of direct injection of S. japonicum eggs through skull into the brain provides a good and easy animal model of neuroschistosomiasis.
建立神经血吸虫病实验模型并研究模型建立的影响因素。
以家兔作为动物模型，采用颅骨钻孔或穿刺两种方式将日本血吸虫卵（1毫克/毫升）直接注入脑部。在第一周和第二周及之后观察家兔症状，随后取出家兔脑部进行病理检查。
注射血吸虫卵后1至2周，家兔出现多种神经症状，如食欲不振、偏瘫、癫痫发作等。病理分析显示90%的家兔存在血吸虫卵肉芽肿炎症反应。
这种通过颅骨直接向脑部注射日本血吸虫卵的新方法提供了一种良好且简便的神经血吸虫病动物模型。
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