Institute of Virology, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany; Department of Microbiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Int J Infect Dis. 2013 Oct;17(10):e897-901. doi: 10.1016/j.ijid.2013.03.022. Epub 2013 May 18.
To define the impact of helminthic infestations and their treatment on viral load and T cell subsets in chronic HIV-1-infected patients.
Two hundred twenty chronic HIV-1-infected Ethiopian patients with (N = 87) and without (N = 133) helminthic infestations were included. To determine the impact of deworming on viral load and T cell subsets, a subset of these patients with (n = 23) and without (n = 20) helminthic infestations were followed longitudinally. Helminth egg loads, plasma HIV RNA levels, and peripheral blood CD4(+) and CD8(+) T cells were determined at baseline and at 12 weeks after antihelminthic treatment.
At baseline, plasma viral load was significantly higher in individuals with (n = 87) than without (n = 133) a helminthic infestation (5.01 log10 vs. 3.41 log10, p < 0.001). Twelve weeks after antihelminthic treatment, plasma HIV RNA levels were reduced in the successfully treated group (p < 0.001). Twelve weeks after antihelminthic treatment, helminth infestations and their treatment had no significant effect on CD4(+) T cell counts. However, helminth-infested individuals had a higher level of CD8(+) T cells at baseline (p < 0.001), which was significantly reduced (p < 0.01) at 12 weeks after antihelminthic treatment.
Helminths were found to be associated with an increased HIV RNA level. Successful treatment of intestinal helminths reduced plasma HIV RNA levels in chronic HIV-1 subtype C infection. Considering the high endemicity of helminths in tropical settings, the management of chronically HIV-infected individuals must include deworming.
确定寄生虫感染及其治疗对慢性 HIV-1 感染患者病毒载量和 T 细胞亚群的影响。
纳入 220 名埃塞俄比亚慢性 HIV-1 感染患者，其中有（N=87）和没有（N=133）寄生虫感染。为了确定驱虫治疗对病毒载量和 T 细胞亚群的影响，对这些患者中的一部分（n=23）和没有寄生虫感染的一部分（n=20）进行了纵向随访。在基线和抗寄生虫治疗后 12 周时，测定了寄生虫卵负荷、血浆 HIV RNA 水平以及外周血 CD4+和 CD8+T 细胞。
基线时，有寄生虫感染的个体（n=87）的血浆病毒载量明显高于无寄生虫感染的个体（n=133）（5.01 log10 与 3.41 log10，p<0.001）。抗寄生虫治疗后 12 周，成功治疗组的血浆 HIV RNA 水平降低（p<0.001）。抗寄生虫治疗后 12 周，寄生虫感染及其治疗对 CD4+T 细胞计数没有显著影响。然而，寄生虫感染的个体在基线时具有更高水平的 CD8+T 细胞（p<0.001），在抗寄生虫治疗后 12 周时显著降低（p<0.01）。
寄生虫与 HIV RNA 水平升高有关。成功治疗肠道寄生虫可降低慢性 HIV-1 型 C 感染患者的血浆 HIV RNA 水平。考虑到热带地区寄生虫的高流行率，慢性 HIV 感染个体的管理必须包括驱虫。
