Department of Paediatric Cardiology, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Göteborg, Sweden.
Semin Fetal Neonatal Med. 2013 Oct;18(5):302-10. doi: 10.1016/j.siny.2013.04.007. Epub 2013 May 18.
Approximately 1-2 per 1000 newborn babies have a cardiac defect that is potentially life-threatening usually because either the systemic or the pulmonary blood flow is dependent on a patent ductus arteriosus. A significant proportion of newborns with such cardiac defects are being discharged from well-baby nurseries without a diagnosis and therefore risk circulatory collapse and death. This risk is greatest for defects with duct-dependent systemic circulation, notably aortic arch obstruction, but is also significant in transposition of the great arteries, for example. The solution to this problem, apart from improving prenatal detection rates, is to introduce effective neonatal screening including routine pulse oximetry.
大约每 1000 个新生儿中就有 1-2 个患有潜在危及生命的心脏缺陷，通常是因为体循环或肺循环依赖未闭的动脉导管。相当一部分患有此类心脏缺陷的新生儿在离开婴儿室时没有得到诊断，因此有循环衰竭和死亡的风险。对于依赖导管的体循环缺陷，如主动脉弓阻塞，风险最大，但大动脉转位也是如此。除了提高产前检出率外，解决这个问题的方法是引入有效的新生儿筛查，包括常规脉搏血氧饱和度测定。
