Ciftci Rumeysa, Tas Faruk, Karabulut Senem, Ciftci Serkan
1Department of Medical Oncology, Istanbul University Institute of Oncology, Istanbul, Turkey; and 2Department of Cardiology, Istanbul Bakirköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Am J Ther. 2015 Jan-Feb;22(1):e17-9. doi: 10.1097/MJT.0b013e318293b10a.
Capecitabine is an oral antineoplastic agent, and phenytoin is an anticonvulsant drug with a narrow therapeutic index. Although the interaction between capecitabine and phenytoin is rare, it may be potentially fatal. This interaction is thought to be at the level of CYP2C9 isoenzyme system in the liver. Here, we present a patient with metastatic breast cancer who developed phenytoin intoxication when using capecitabine and phenytoin together. Closely monitoring plasma phenytoin levels is essential if capecitabine is used with phenytoin concurrently.
卡培他滨是一种口服抗肿瘤药，而苯妥英是一种治疗指数狭窄的抗惊厥药物。虽然卡培他滨与苯妥英之间的相互作用很少见，但可能具有潜在致命性。这种相互作用被认为发生在肝脏中的CYP2C9同工酶系统水平。在此，我们报告一名转移性乳腺癌患者，在同时使用卡培他滨和苯妥英时发生了苯妥英中毒。如果同时使用卡培他滨和苯妥英，密切监测血浆苯妥英水平至关重要。
