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新辅助同步卡培他滨和放疗治疗直肠腺癌期间苯妥英中毒：药物相互作用病例报告

Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction.

作者信息

McGrath Clare, Munro Amy, Goel Rakesh, Linden Kelly, Dennis Kristopher

机构信息

Radiation Oncology, The Ottawa Hospital Cancer Centre, Ottawa, CAN.

Radiation Oncology, McMaster University, Hamilton, CAN.

出版信息

Cureus. 2018 Nov 23;10(11):e3625. doi: 10.7759/cureus.3625.

DOI:10.7759/cureus.3625
PMID:30697501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6347445/
Abstract

Phenytoin toxicity occurs when serum levels exceed the therapeutic level, leading to symptoms such as nystagmus, slurred speech, and decreased coordination. This toxicity is sometimes caused by drug interactions. Interactions between phenytoin and capecitabine are not commonly documented. We report the case of a 52-year-old man taking phenytoin for atypical meningioma who developed symptoms of phenytoin toxicity while receiving capecitabine in the treatment of rectal adenocarcinoma.

摘要

当血清水平超过治疗水平时，就会发生苯妥英中毒，导致眼球震颤、言语不清和协调性下降等症状。这种毒性有时是由药物相互作用引起的。苯妥英和卡培他滨之间的相互作用鲜有文献记载。我们报告了一例52岁男性病例，该患者因非典型脑膜瘤服用苯妥英，在接受卡培他滨治疗直肠腺癌时出现了苯妥英中毒症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/794d/6347445/9420588e0c02/cureus-0010-00000003625-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/794d/6347445/60bce4361765/cureus-0010-00000003625-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/794d/6347445/9420588e0c02/cureus-0010-00000003625-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/794d/6347445/60bce4361765/cureus-0010-00000003625-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/794d/6347445/9420588e0c02/cureus-0010-00000003625-i02.jpg

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本文引用的文献

1
Pharmacokinetic model analysis of interaction between phenytoin and capecitabine.苯妥英钠与卡培他滨相互作用的药代动力学模型分析
Int J Clin Pharmacol Ther. 2016 Sep;54(9):657-65. doi: 10.5414/CP202416.
2
Combination of capecitabine and phenytoin may cause phenytoin intoxication: a case report.卡培他滨与苯妥英钠联用可能导致苯妥英钠中毒：一例报告
Am J Ther. 2015 Jan-Feb;22(1):e17-9. doi: 10.1097/MJT.0b013e318293b10a.
3
Phenytoin poisoning.苯妥英中毒。
Neurocrit Care. 2005;3(2):161-70. doi: 10.1385/NCC:3:2:161.
4
Capecitabine: a review.卡培他滨：综述
Clin Ther. 2005 Jan;27(1):23-44. doi: 10.1016/j.clinthera.2005.01.005.
5
Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports.氟嘧啶（5-氟尿嘧啶/卡培他滨）所致苯妥英钠中毒：三例病例报告
Br J Cancer. 2003 Aug 18;89(4):615-6. doi: 10.1038/sj.bjc.6601137.
6
Phenytoin toxicity as a result of 5-fluorouracil administration.因使用5-氟尿嘧啶导致苯妥英中毒。
N Z Med J. 2002 Aug 9;115(1159):U124.
7
Phenytoin and fluorouracil interaction.苯妥英与氟尿嘧啶的相互作用。
Ann Pharmacother. 2001 Nov;35(11):1367-70. doi: 10.1345/aph.1A051.
8
Pharmacokinetic drug interactions with phenytoin (Part I).苯妥英的药代动力学药物相互作用（第一部分）。
Clin Pharmacokinet. 1990 Jan;18(1):37-60. doi: 10.2165/00003088-199018010-00003.