Reinemeyer C R, DeNovo R C
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071.
Am J Vet Res. 1990 Jun;51(6):932-4.
The efficacy of paste and granule formulations of pyrantel pamoate against concurrent infections of Toxocara cati and Ancylostoma tubaeforme in cats was examined in a controlled trial. Three groups of 8 cats received either no medication (controls) or pyrantel pamoate in paste or granule formulations at a dosage of 20 mg/kg of body weight. After administration of the paste formulation, fecal egg counts of A tubaeforme and T cati were decreased by 98.6 and 96.4%, respectively, and 100% of hookworms and 93.5% of ascarids were removed from the intestine. After administration of the granule formulation, fecal egg counts of A tubaeforme and T cati were decreased by 99.4 and 78.2%, respectively, and 100% of adult hookworms and 88.9% of ascarids were removed. All reductions of egg counts and worm numbers were significant (P less than 0.01). The clinical safety of pyrantel pamoate was evaluated in 4- to 6-week-old kittens. Three groups of 10 kittens received either no medication (controls) or pyrantel pamoate in paste or granule formulations at the rate of 100 mg/kg for 3 consecutive days. Adverse effects were not observed in young kittens following administration of the high dose of pyrantel pamoate.
在一项对照试验中，研究了吡喹酮糊剂和颗粒剂对猫同时感染猫弓首蛔虫和管状钩口线虫的疗效。三组，每组8只猫，分别不接受药物治疗（对照组）或接受剂量为20mg/kg体重的吡喹酮糊剂或颗粒剂。给予糊剂后，管状钩口线虫和猫弓首蛔虫的粪便虫卵计数分别下降了98.6%和96.4%，100%的钩虫和93.5%的蛔虫从肠道中被清除。给予颗粒剂后，管状钩口线虫和猫弓首蛔虫的粪便虫卵计数分别下降了99.4%和78.2%，100%的成虫钩虫和88.9%的蛔虫被清除。所有虫卵计数和虫体数量的减少均具有显著性（P小于0.01）。在4至6周龄的小猫中评估了吡喹酮的临床安全性。三组，每组10只小猫，分别不接受药物治疗（对照组）或接受剂量为100mg/kg的吡喹酮糊剂或颗粒剂，连续给药3天。给予高剂量吡喹酮后，幼猫未观察到不良反应。
