人工角膜

The artificial cornea.

作者信息

Polisetti Naresh, Islam Mohammad Mirazul, Griffith May

机构信息

Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany.

出版信息

Methods Mol Biol. 2013;1014:45-52. doi: 10.1007/978-1-62703-432-6_2.

DOI:10.1007/978-1-62703-432-6_2

PMID:23690003

Abstract

Human corneal transplantation to date suffers from the shortage of good-quality donor tissue, and in some conditions, allografting is contraindicated. A range of artificial replacements to donor allograft corneas have been developed. These range from keratoprostheses (KPro) that replace basic corneal functions of light transmission and protection to regenerative medicine strategies for regenerating one or more layers of the human cornea. This chapter reviews the advances made in developing artificial corneas or more accurately, artificial alternatives to donor allograft corneas for ocular application.

摘要

迄今为止，人类角膜移植面临优质供体组织短缺的问题，并且在某些情况下，同种异体移植是禁忌的。已经开发出一系列替代供体同种异体角膜的人工替代品。这些替代品包括角膜假体（KPro），其可替代角膜的基本透光和保护功能，以及用于再生人角膜一层或多层的再生医学策略。本章回顾了在开发人工角膜方面取得的进展，或者更准确地说，是用于眼部应用的替代供体同种异体角膜的人工替代品方面取得的进展。