Najmi Varzaneh Farnaz, Sharifi Farshad, Hossein-Nezhad Arash, Mirarefin Mojde, Maghbooli Zhila, Ghaderpanahi Maryam, Larijani Bagher, Fakhrzadeh Hossein
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Acta Med Iran. 2013 May 7;51(4):236-41.
Longevity is a multifaceted trait in which variety of genes and environmental factors are involved. Newly, the role of vitamin D has been revived regarding its potential advantage on delaying the aging process. Vitamin D exerts its effect through vitamin D receptor (VDR). VDR-FokI is the only polymorphism which alters the VDR length. We examined the frequency of FokI genotypes in old age population as compared to young adults to determine the discerning genotype of FokI polymorphism leading to longer living. In addition, to highlight the position of FokІ polymorphism in quality of life; a cognitive function assessment was performed. 728 participants participated in this study of which 166 individuals were elderly residents of Kahrizak Charity Foundation. The rest were participants of Iranian Multicenter Osteoporosis Study (IMOS). Genomic DNA was extracted from peripheral blood and VDR genotype was detected by the polymerase chain reaction. The participants in the elderly group underwent a cognitive function assessment. Cognitive function was measured with the mini mental state examination (MMSE). Data were analyzed by SPSS 16.5. The prevalence of ff genotype showed 48% decrease in elderly population as compared to young adults (P=0.06). In addition, F allele was over-represented in the elderly group as compared to controls (P=0.05). Also, "FF" participants of elderly group had higher MMSE as compared to "ff" genotype (18.16Vs17.12). Our data suggest that single nucleotide polymorphisms (SNPs) in FokI may be possibly involved in longevity and cognitive function.
长寿是一个多方面的特征，涉及多种基因和环境因素。最近，维生素D在延缓衰老过程中的潜在优势方面的作用又被重新关注。维生素D通过维生素D受体（VDR）发挥作用。VDR-FokI是唯一能改变VDR长度的多态性。我们比较了老年人群和年轻人中FokI基因型的频率，以确定导致更长寿命的FokI多态性的鉴别基因型。此外，为了突出FokІ多态性在生活质量中的地位，进行了认知功能评估。728名参与者参与了这项研究，其中166人是卡里扎克慈善基金会的老年居民。其余是伊朗多中心骨质疏松症研究（IMOS）的参与者。从外周血中提取基因组DNA，并通过聚合酶链反应检测VDR基因型。老年组的参与者接受了认知功能评估。用简易精神状态检查表（MMSE）测量认知功能。数据用SPSS 16.5进行分析。与年轻人相比，老年人群中ff基因型的患病率下降了48%（P = 0.06）。此外，与对照组相比，老年组中F等位基因的比例过高（P = 0.05）。而且，老年组的“FF”参与者的MMSE得分高于“ff”基因型（18.16对17.12）。我们的数据表明，FokI中的单核苷酸多态性（SNP）可能与长寿和认知功能有关。
