Koike A, Matsumoto K, Suzumura K, Saegusa J, Inamura Y, Kojima T, Kato K, Kanemitsu T, Naruse T, Yamamoto S
1st Dept. of Surgery, Aichi Medical University.
Gan To Kagaku Ryoho. 1990 Jul;17(7):1309-14.
Efficacy of a 48-hour infusion of 5-FU in patients with stage IV gastric cancer was investigated. A one-cycle regimen consisted of a 48-hour infusion of 5-FU (30 mg/kg/24 hours) every week for 6 weeks. Fourteen patients with stage IV gastric cancer who underwent absolutely non-curative gastrectomy, received 5-FU infusion postoperatively. Ten of the 14 received more than 2 cycles. Survival rates in these patients (group I) were evaluated by Kaplan-Meier method and compared with those of matched pair controls (group II) who received other anticancer agents. Side effects were generally mild. Nausea during infusion was observed in only 3 cases. The 50% survival period was 393 days in group I and 135 days in group II, respectively. The survival curve in group I was significantly higher than in group II (p = 0.05). From these results, this treatment is considered to be very effective.
研究了48小时输注5-氟尿嘧啶（5-FU）对IV期胃癌患者的疗效。一个疗程方案为每周进行一次48小时的5-FU输注（30mg/kg/24小时），共6周。14例接受了绝对非根治性胃切除术的IV期胃癌患者术后接受了5-FU输注。14例患者中有10例接受了超过2个疗程的治疗。采用Kaplan-Meier法评估这些患者（I组）的生存率，并与接受其他抗癌药物的配对对照患者（II组）的生存率进行比较。副作用一般较轻。仅3例患者在输注期间出现恶心。I组和II组的50%生存期分别为393天和135天。I组的生存曲线明显高于II组（p=0.05）。根据这些结果，该治疗方法被认为非常有效。
