O'Reilly R, Rusnak C
University of Saskatchewan, Saskatoon.
CMAJ. 1990 Mar 15;142(6):585-9.
We reviewed the charts of 476 patients admitted to a university teaching hospital to determine whether sedative-hypnotic drugs (SHDs) were being used excessively and to examine the use of SHDs as hypnotics. The frequency of medical and surgical indications for barbiturates and benzodiazepines or other minor tranquillizers as well as the use of such drugs were compared among different groups of patients and specialty wards. Of the patients 29% had a regular order and 40% had a PRN order; only 77% of the PRN orders were administered. A total of 215 patients (45%) received an SHD during their hospital stay, and 160 (34%) received the drug as a hypnotic. Medical indications accounted for 49% of the regular orders but only 2% of the PRN orders; moreover, 89% of all the PRN orders were for insomnia. On average, patients receiving SHDs as hypnotics were older (p less than 0.05) and stayed longer in hospital (p less than 0.01) than those who did not; however, no patient on the geriatric or pediatric ward received an SHD as a hypnotic during the hospital stay. The differences in use between patient groups may have been influenced by orientation of ward staff. Physicians should review their rationale for prescribing hypnotics and avoid routine orders on admission.
我们查阅了一所大学教学医院476名住院患者的病历,以确定镇静催眠药物(SHDs)是否被过度使用,并研究SHDs作为催眠药的使用情况。比较了不同患者组和专科病房中巴比妥类药物、苯二氮卓类药物或其他轻度镇静剂的医疗和手术适应症的频率以及此类药物的使用情况。在这些患者中,29%有常规医嘱,40%有必要时医嘱;只有77%的必要时医嘱得到了执行。共有215名患者(45%)在住院期间接受了SHD,160名患者(34%)接受该药物作为催眠药。医疗适应症占常规医嘱的49%,但仅占必要时医嘱的2%;此外,所有必要时医嘱的89%是用于治疗失眠。平均而言,接受SHD作为催眠药的患者比未接受的患者年龄更大(p<0.05),住院时间更长(p<0.01);然而,老年病房或儿科病房的患者在住院期间均未接受SHD作为催眠药。患者组之间使用情况的差异可能受到病房工作人员工作导向的影响。医生应重新审视其开具催眠药的理由,并避免在入院时开具常规医嘱。