Dworkin L D, Feiner H D, Parker M, Randazzo J
Department of Medicine, New York University Medical Center, New York 10016.
Am J Hypertens. 1990 Jun;3(6 Pt 1):444-50. doi: 10.1093/ajh/3.6.444.
To examine the effects of dietary calcium supplementation on systemic and renal hemodynamics and glomerular injury in experimental hypertension, rats with desoxycorticosterone-salt hypertension were fed either standard chow, containing 1% calcium by weight, or chow supplemented with calcium carbonate to achieve a calcium content of 2% by weight. Ingestion of calcium carbonate failed to reduce systemic blood pressure, but was associated with increased proteinuria and morphologic evidence of glomerular injury. Micropuncture studies revealed that afferent arteriolar resistance was reduced and glomerular capillary pressure further increased in the high calcium group. Thus, calcium carbonate, in moderate amounts, not only failed to ameliorate systemic hypertension but, paradoxically, worsened intrarenal hypertension and injury in rats with mineralocorticoid-induced hypertension.
为研究膳食补钙对实验性高血压大鼠全身及肾脏血流动力学和肾小球损伤的影响，给脱氧皮质酮-盐性高血压大鼠喂食标准饲料（按重量计含钙1%）或添加碳酸钙的饲料，使钙含量达到按重量计2%。摄入碳酸钙未能降低全身血压，但与蛋白尿增加及肾小球损伤的形态学证据有关。微穿刺研究显示，高钙组入球小动脉阻力降低，肾小球毛细血管压力进一步升高。因此，适量的碳酸钙不仅未能改善全身高血压，反而反常地加重了盐皮质激素诱导的高血压大鼠的肾内高血压和损伤。
