Department of Dermatology and Venereology, University of Modena and Reggio Emilia, IT-41124 Modena, Italy.
Acta Derm Venereol. 2013 Nov;93(6):650-5. doi: 10.2340/00015555-1588.
The dermoscopic descriptor "negative pigment network" (NPN) has been reported in several types of melanocytic and non-melanocytic lesions, although it has a higher frequency of association with melanoma and Spitz naevus. In a study of 401 consecutive melanomas, excluding facial, acral and mucosal locations, the frequency and variability of NPN were investigated, and the results of NPN correlated with clinical and histopathological data. NPN of any extension was found in 27% of melanomas, most frequently invasive and arising from a naevus on the trunk of young subjects. Seven percent of melanomas in the study population showed presence of NPN in more than half of the lesion area; most of these did not show typical dermoscopic melanoma features. The authors propose a new melanoma subtype, in which extensive NPN should be considered as a diagnostic indicator.
“阴性色素网（NPN）”这一皮肤镜描述语已在多种黑色素细胞和非黑色素细胞病变中被报道，尽管它与黑色素瘤和 Spitz 痣的相关性更高。在一项对 401 例连续的黑色素瘤（不包括面部、肢端和黏膜部位）的研究中，研究人员调查了 NPN 的频率和可变性，并将 NPN 的结果与临床和组织病理学数据相关联。研究发现，27%的黑色素瘤存在任何程度的 NPN，最常见于侵袭性黑色素瘤，且起源于年轻患者躯干上的痣。在研究人群中，有 7%的黑色素瘤在超过一半的病变区域存在 NPN；其中大多数未表现出典型的皮肤镜黑色素瘤特征。作者提出了一种新的黑色素瘤亚型，其中广泛的 NPN 应被视为一种诊断指标。
