Department of Neurointervention, King Edward Memorial Hospital, Pune, India.
Stroke. 2013 Jul;44(7):2000-3. doi: 10.1161/STROKEAHA.113.001446. Epub 2013 May 21.
To demonstrate the safety and efficacy of balloon-expandable intracranial stents in patients with intracranial atherosclerotic lesions (>70% stenosis) who were symptomatic despite being on optimum medical therapy.
Between April 2004 and May 2012, 182 patients underwent intracranial stenting in our institution. All patients had symptoms despite being on optimum medical therapy. Clinical follow-up was done at 1, 3, 6, and 12 months. Angiographic follow-up was done at 1 year in 121 patients.
Technical success was achieved in 97.44% of the cases. The incidence of all strokes at 1 month after procedure was 11 (5.64%), of which 2 (1.02%) were major, both related to stent thrombosis not responding to tirofiban, and 9 (4.61%) were minor. Periprocedural minor stroke was seen in 9 patients. There were 2 deaths in our study (mortality=1.09%).
Treatment of intracranial atherosclerotic disease with balloon-expandable intracranial stents is a safe and effective method with acceptable adverse events, especially in patients who failed medical therapy and were symptomatic despite being on optimum medical therapy.
旨在展示在接受最佳药物治疗后仍有症状的颅内动脉粥样硬化病变（狭窄>70%）患者中，使用球囊扩张颅内支架的安全性和有效性。
2004 年 4 月至 2012 年 5 月期间，我院对 182 例患者进行了颅内支架置入术。所有患者均存在药物治疗后仍有症状的情况。进行了 1、3、6 和 12 个月的临床随访。121 例患者在 1 年时进行了血管造影随访。
97.44%的病例达到了技术上的成功。术后 1 个月的所有卒中发生率为 11 例（5.64%），其中 2 例（1.02%）为大卒，均与支架内血栓形成（对替罗非班无反应）有关，9 例（4.61%）为小卒。9 例患者发生围手术期小卒中。研究中出现 2 例死亡（死亡率=1.09%）。
使用球囊扩张颅内支架治疗颅内动脉粥样硬化疾病是一种安全有效的方法，不良事件可接受，尤其适用于药物治疗失败且最佳药物治疗后仍有症状的患者。
