Wintermark Pia, Lechpammer Mirna, Warfield Simon K, Kosaras Bela, Takeoka Masanori, Poduri Annapurna, Madsen Joseph R, Bergin Ann M, Whalen Stephen, Jensen Frances E
1Division of Newborn Medicine, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, QC, Canada.
J Child Neurol. 2013 Nov;28(11):1474-1482. doi: 10.1177/0883073813488666. Epub 2013 May 21.
Focal cortical dysplasia is the most common malformation of cortical development, causing intractable epilepsy. This study investigated the relationship between brain perfusion and microvessel density in 7 children with focal cortical dysplasia. The authors analyzed brain perfusion measurements obtained by magnetic resonance imaging of 2 of the children and the microvessel density of brain tissue specimens obtained by epilepsy surgery on all of the children. Brain perfusion was approximately 2 times higher in the area of focal cortical dysplasia compared to the contralateral side. The microvessel density was nearly double in the area of focal cortical dysplasia compared to the surrounding cortex that did not have morphological abnormalities. These findings suggest that hyperperfusion can be related to increased microvessel density in focal cortical dysplasia rather than only to seizures. Further investigations are needed to determine the relationship between brain perfusion, microvessel density, and seizure activity.
局灶性皮质发育不良是最常见的皮质发育畸形，可导致难治性癫痫。本研究调查了7例局灶性皮质发育不良患儿的脑灌注与微血管密度之间的关系。作者分析了2例患儿通过磁共振成像获得的脑灌注测量结果，以及所有患儿通过癫痫手术获得的脑组织标本的微血管密度。与对侧相比，局灶性皮质发育不良区域的脑灌注大约高2倍。与无形态学异常的周围皮质相比，局灶性皮质发育不良区域的微血管密度几乎增加了一倍。这些发现表明，高灌注可能与局灶性皮质发育不良中微血管密度增加有关，而不仅仅与癫痫发作有关。需要进一步研究以确定脑灌注、微血管密度和癫痫活动之间的关系。
