Naghnaeian Mina, Samienasab Mohammadreza, Mirmohammadsadeghi Mohsen, Rabani Majid, Pourmoghaddas Ali, Behnemun Mahsa
Resident, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
ARYA Atheroscler. 2013 Jan;9(1):11-5.
Atrial fibrillation (AF) after coronary artery bypass graft (CABG) surgery is a common problem. In this study, we sought to evaluate the safety and tolerance of continuous atrial pacing after CABG. We hypothesized that a strategy of temporary atrial pacing after CABG would reduce the incidence of postoperative AF.
During 2012, CABG candidates over 18 years of age at Sina Hospital (Isfahan, Iran) were recruited. Before surgery, the participants were randomly assigned to two groups of ventricular pacing and left atrial ventricular pacing (atrial pacing). The primary end point of the study was the initial occurrence of AF or atrial flutter with a ventricular rate greater than 100 beats per minute for 10 consecutive minutes or completion of the 48-hour monitoring period.
We evaluated 64 consecutive CABG candidates with sinus rhythm. They were allocated to two groups of ventricular pacing and atrial ventricular pacing (n = 32 in each group). Three patients in the ventricular pacing group (10%) and six in the atrial ventricular pacing group (22%) had sustained AF during the first 48 hours after CABG (P = 0.18 according to Fisher's exact test).
Continuous atrial pacing in the postoperative setting is safe and well-tolerated. In this study, we found that temporary atrial pacing increased the frequency of postoperative AF. Since the difference between the two groups was not significant, larger studies are required to determine the exact relation between pacing method and AF.
冠状动脉旁路移植术(CABG)后发生心房颤动(AF)是一个常见问题。在本研究中,我们试图评估CABG术后持续心房起搏的安全性和耐受性。我们假设CABG术后临时心房起搏策略会降低术后AF的发生率。
2012年期间,招募了伊朗伊斯法罕市新浪医院18岁以上的CABG候选患者。手术前,参与者被随机分为心室起搏组和左心房心室起搏组(心房起搏组)。研究的主要终点是首次出现AF或心房扑动,心室率连续10分钟大于每分钟100次,或完成48小时监测期。
我们评估了64例连续的窦性心律CABG候选患者。他们被分为心室起搏组和心房心室起搏组(每组n = 32)。心室起搏组有3例患者(10%),心房心室起搏组有6例患者(22%)在CABG术后的前48小时内发生持续性AF(根据Fisher精确检验,P = 0.18)。
术后持续心房起搏是安全且耐受性良好的。在本研究中,我们发现临时心房起搏增加了术后AF的发生率。由于两组之间的差异不显著,需要更大规模的研究来确定起搏方法与AF的确切关系。