Novovic Srdan, Malmstrøm Marie Louise, Møller Andersen Anders, Jørgensen Lars Nannestad, Philipsen Else, Schmidt Palle Nordblad, Hansen Mark Berner
Kirurgisk Afdeling K, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV, Denmark.
Ugeskr Laeger. 2013 May 20;175(21):1478-81.
Severe acute pancreatitis (SAP) is associated with a high morbidity and a mortality risk of up to 20%. Although much progress has occurred during the latest couple of years, there are still some major controversies on important issues such as monitoring, fluid therapy, antibiotic treatment, and nutrition. In this article we describe the underlying, pathophysiologic mechanisms responsible for organ failure in SAP, and the rationale for monitoring and conservative treatment of SAP.
重症急性胰腺炎(SAP)的发病率很高,死亡率风险高达20%。尽管在最近几年已经取得了很大进展,但在监测、液体治疗、抗生素治疗和营养等重要问题上仍存在一些重大争议。在本文中,我们描述了SAP中导致器官衰竭的潜在病理生理机制,以及SAP监测和保守治疗的基本原理。