Department of Inspection and Research Division, Yokohama City Institute of Public Health, Kanagawa, Japan.
Jpn J Infect Dis. 2013;66(3):226-31. doi: 10.7883/yoken.66.226.
A survey of mumps infections from 1999 to 2010 was conducted in Yokohama City, Japan, and 17 cases--including 4 cases of aseptic meningitis--were positive for mumps virus (MuV). Based on the phylogenetic analysis of the small hydrophobic gene of the MuV genome, 3, 2, and 12 of the isolates were classified into genotypes B, L, and G, respectively. The results were supported by phylogenetic analysis of hemagglutinin-neuraminidase genes. The 3 isolates of genotype B, obtained in 2000, 2004, and 2007, were closely related to indigenous lineages and vaccine strains in Japan. Two isolates obtained from 1999 to 2000 were assigned to genotype L. Twelve isolates obtained from 2000 to 2010 were classified into genotype G, in which 8 isolates obtained from 2000 to 2006 and 4 isolates obtained in 2010 were closely related to MuVi/Gloucester.GBR/32.96 and MuVi/London.GBR/0.03, respectively. Precise analyses of nucleotide sequences suggested that the 4 viruses isolated in 2010 were not directly derived from the evolution of MuV existing before 2006 in the Yokohama area.
日本横滨市对 1999 年至 2010 年的腮腺炎感染进行了调查，17 例（包括 4 例无菌性脑膜炎）腮腺炎病毒（MuV）检测呈阳性。基于 MuV 基因组小疏水基因的系统发生分析，3、2 和 12 个分离株分别归类为基因型 B、L 和 G。血凝素神经氨酸酶基因的系统发生分析支持了这一结果。2000 年、2004 年和 2007 年获得的 3 株基因型 B 分离株与日本本土谱系和疫苗株密切相关。1999 年至 2000 年获得的 2 株分离株被分配到基因型 L。2000 年至 2010 年获得的 12 株分离株被归类为基因型 G，其中 2000 年至 2006 年获得的 8 株和 2010 年获得的 4 株与 MuVi/Gloucester.GBR/32.96 和 MuVi/London.GBR/0.03 分别密切相关。核苷酸序列的精确分析表明，2010 年分离的 4 株病毒并非直接源自 2006 年以前横滨地区存在的 MuV 进化。
