Department of Paediatric Haematology, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
Arch Dis Child. 2013 Jul;98(7):545-7. doi: 10.1136/archdischild-2012-303160. Epub 2013 May 22.
To assess the sensitivity of an adult-derived red cell distribution width (RDW) reference limit in the detection of iron deficiency in young children.
Haematological analysis performed on a cohort of 13-month-old healthy term infants of North European ancestry.
21/98 infants were iron-deficient (>2.5% hypochromic red cells). Of the remaining 77, 35 with RDW >13.9% also had evidence of incipient iron deficiency on the basis of significantly lower haemoglobin (11.5 vs 11.8 g/dl, p=0.046), mean cell volume (75.6 vs 77.8 fl, p=0.002) and mean cell haemoglobin (25.4 vs 26.2 pg, p=0.002) values and higher zinc protoporphyrin (55 vs 44 μmol/molhaem, p<0.001) values than those of the 42 with RDW ≤13.9%.
An adult-derived RDW reference limit has utility in screening for iron deficiency at the age of 13 months. The incidence of non-anaemic iron deficiency in this group was 52.8%.
评估成人红细胞分布宽度（RDW）参考范围在检测幼儿缺铁中的敏感性。
对来自北欧血统的 13 个月大的健康足月婴儿队列进行血液学分析。
98 名婴儿中有 21 名缺铁（>2.5%的低色素红细胞）。在其余 77 名婴儿中，RDW>13.9%的 35 名婴儿也有铁缺乏的早期证据，根据血红蛋白（11.5 与 11.8 g/dl，p=0.046）、平均细胞体积（75.6 与 77.8 fl，p=0.002）和平均细胞血红蛋白（25.4 与 26.2 pg，p=0.002）值显著降低以及锌原卟啉（55 与 44 μmol/molhaem，p<0.001）值升高。
成人衍生的 RDW 参考范围可用于 13 个月龄时筛查缺铁。该组中非贫血性缺铁的发生率为 52.8%。
