老年松果体：雄性大鼠松果体细胞数量及肾上腺素能神经支配的减少

The aged pineal gland: reduction in pinealocyte number and adrenergic innervation in male rats.

作者信息

Reuss S, Spies C, Schröder H, Vollrath L

机构信息

Department of Anatomy, Johannes Gutenberg University, Mainz, West Germany.

出版信息

Exp Gerontol. 1990;25(2):183-8. doi: 10.1016/0531-5565(90)90049-8.

DOI:10.1016/0531-5565(90)90049-8

PMID:2369932

Abstract

Previous biochemical and physiological studies point to an age-related loss of pineal function. Morphological studies revealed increased connective tissue and glial cell numbers in the gland. In the present study we investigated whether the number of parenchymal cells and the incidence of sympathetic fibers in the rat pineal gland is altered with advanced age. The comparison of pineal histology of young adult (2-3 months old) and aged animals (22-26 months old) showed that pinealocyte number in old animals is decreased by 18%. In addition, sympathetic innervation of the gland as revealed by glyoxylic acid fluorescence is drastically reduced in these animals. It is concluded that the age-related decline in pineal metabolism may be due to both decreased parenchymal cell number and reduced sympathetic innervation.

摘要

先前的生物化学和生理学研究表明，松果体功能会随着年龄增长而衰退。形态学研究显示，松果体内的结缔组织和神经胶质细胞数量增加。在本研究中，我们调查了大鼠松果体中实质细胞数量和交感神经纤维发生率是否会随着年龄增长而改变。对年轻成年（2 - 3个月大）和老年动物（22 - 26个月大）的松果体组织学进行比较，结果显示老年动物的松果体细胞数量减少了18%。此外，这些动物中通过乙醛酸荧光显示的腺体交感神经支配显著减少。得出的结论是，与年龄相关的松果体代谢衰退可能是由于实质细胞数量减少和交感神经支配减少共同导致的。