Saratikov A S, Vengerovskiĭ A I, Sedykh I M
Farmakol Toksikol. 1990 Mar-Apr;53(2):38-40.
The hepatoprotective agents silybinin, essentiale and eplir (the complex of phospholipids and caratinoids from the mud) prevent in D-galactosamine-induced intoxication of rats the development of hepatitis, hepatocyte necrosis, a decrease in hepatocytes of the activity of the enzymes of mitochondria and endoplasmic reticulum, labilization of lysosomes. These drugs stimulate D-galactosamine-suppressed antitoxic function of the liver: they increase the contents of RNA, cytochromes P-450, b5, the activity of amidopyrine-D-demethylase, hydroxylases of hexobarbital and aniline, improve the activity of the respiratory chain of microsomes, counteract inactivation of cytochrome P-450 into cytochrome P-420. Essentiale and eplir activate conjugation of xenobiotics with reduced glutathione.
保肝剂水飞蓟宾、易善力和依普利（来自泥浆的磷脂和类胡萝卜素复合物）可预防大鼠因D-半乳糖胺诱导的中毒而引发的肝炎、肝细胞坏死、线粒体和内质网酶活性在肝细胞中的降低以及溶酶体的不稳定。这些药物可刺激D-半乳糖胺抑制的肝脏抗毒功能：它们增加RNA、细胞色素P-450、b5的含量，提高氨基比林-N-脱甲基酶、己巴比妥和苯胺羟化酶的活性，改善微粒体呼吸链的活性，对抗细胞色素P-450向细胞色素P-420的失活。易善力和依普利可激活外源性物质与还原型谷胱甘肽的结合。
