异基因造血干细胞移植后，采用过继性T细胞转移治疗难治性巨细胞病毒、EB病毒或腺病毒感染。
Adoptive T-cell transfer for refractory viral infections with cytomegalovirus, Epstein-Barr virus or adenovirus after allogeneic stem cell transplantation.
作者信息
Feucht J, Joachim L, Lang P, Feuchtinger T
机构信息
Pediatric Hematology/Oncology, University Children's Hospital Tübingen, Germany.
出版信息
Klin Padiatr. 2013 May;225(3):164-9. doi: 10.1055/s-0033-1333749. Epub 2013 May 22.
Viral infections after allogeneic stem cell transplantation (SCT) are an important cause of morbidity and mortality as SCT can expose patients to a transient state of combined immunodeficieny. Most viral infections after SCT are caused by the endogenous reactivation of persistent pathogens such as adenovirus (ADV), cytomegalovirus (CMV), and Epstein-Barr-virus (EBV). The control of these infections will ultimately depend on the restoration of adequate T-cell immunity.
异基因造血干细胞移植（SCT）后的病毒感染是发病和死亡的重要原因，因为SCT可使患者处于短暂的联合免疫缺陷状态。SCT后的大多数病毒感染是由持续性病原体如腺病毒（ADV）、巨细胞病毒（CMV）和爱泼斯坦-巴尔病毒（EBV）的内源性再激活引起的。这些感染的控制最终将取决于足够的T细胞免疫力的恢复。
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