Nordic Bioscience Biomarkers and Research, 2730, Herlev, Denmark.
Calcif Tissue Int. 2014 Jan;94(1):88-97. doi: 10.1007/s00223-013-9741-7. Epub 2013 May 23.
In the bone remodeling process that takes place throughout the skeleton at bone multicellular units, intercellular communication processes are crucial. The osteoblast lineage has long been known to program osteoclast formation and hence resorption, but the preservation of bone mass and integrity requires tight control of remodeling. This needs local controls that ensure availability of mesenchymal precursors and the provision of local signals that promote differentiation through the osteoblast lineage. Some signals can come from growth factors released from resorbed bone matrix, and there is increasing evidence that the osteoclast lineage itself produces factors that can either enhance or inhibit osteoblast differentiation and hence bone formation. A number of such factors have been identified from predominantly in vitro experiments. The coupling of bone formation to resorption is increasingly recognized as a complex, dynamic process that results from the input of many local factors of cell and matrix origin that can either promote or inhibit bone formation.
在骨骼多细胞单位中发生的整个骨骼的骨重塑过程中，细胞间通讯过程至关重要。长期以来，成骨细胞谱系被认为可以调控破骨细胞的形成和吸收，但是骨量和骨完整性的维持需要对重塑进行严格控制。这需要局部控制，以确保间充质前体的可用性，并提供促进通过成骨细胞谱系分化的局部信号。一些信号可以来自从吸收的骨基质中释放的生长因子，并且越来越多的证据表明破骨细胞谱系本身可以产生可以增强或抑制成骨细胞分化从而促进骨形成的因子。已经从主要的体外实验中鉴定出了许多这样的因子。骨形成与吸收的偶联被越来越多地认为是一种复杂的动态过程，是由许多细胞和基质来源的局部因子的输入引起的，这些因子可以促进或抑制骨形成。
