Luca Alina Costina, Begezsan Isabela Ioana, Iordache C
University of Medicine and Pharmacy Grigore T Popa Iasi, Faculty of Medicine.
Rev Med Chir Soc Med Nat Iasi. 2012 Oct-Dec;116(4):1028-32.
Infectious endocarditis (IE) represents a rare pathology in children, but with lethal potential. The goal of the therapy is fast and total eradication of the infection.
To study particularities in diagnosis and treatment for infectious endocarditis in children.
Children with infectious endocarditis hospitalized between January 2007 - February 2012 in the Cardiology Department of the ,,Sfânta Maria" Children Emergency Hospital of lasi have been included in the study.
The patients are aged between 23 days and 16 years, the average age being 4 years old. At approximately 88% of the patients (14 cases), the endocardial damage appeared in the pre-existent valvular lesions, specially mitral and aortal. As associated congenital malformations, the patients prevailingly presented ventricular septal defect, mitral valve prolapse, arterial canal persistence, aortic stenosis, coarctation of the aorta. Blood cultures were collected and the most frequent identified etiological agents were: Staphylococcus coagulase-positive, Streptococcus mitis, Staphylococcus speciae coagulase-negative, Staphylococcus haemolyticus, Streptococcus bovis, Escherichia coli, for which the antibiogram showed sensitivity for beta-lactam, cephalosporins, glycopeptides, trimethoprim-sulfamethoxazole, rifampicin, quinolone, lincosamides, oxazolidinones, and thus specific treatment was set up according to the antibiogram.
The infectious endocarditis is a serious disease that affects young age too, leading towards exitus in some cases. Diagnostic imaging and early blood cultures are of relevance in order to intervene promptly. The treatment must be targeted and applied as fast as possible.
感染性心内膜炎（IE）在儿童中是一种罕见的病症，但具有致命风险。治疗的目标是快速且彻底地根除感染。
研究儿童感染性心内膜炎的诊断和治疗特点。
纳入2007年1月至2012年2月在雅西“圣玛丽亚”儿童医院心内科住院的感染性心内膜炎患儿。
患者年龄在23天至16岁之间，平均年龄为4岁。约88%的患者（14例）的心内膜损伤出现在先前存在的瓣膜病变中，特别是二尖瓣和主动脉瓣。作为相关的先天性畸形，患者主要表现为室间隔缺损、二尖瓣脱垂、动脉导管未闭、主动脉狭窄、主动脉缩窄。采集了血培养样本，最常见的病原体为：凝固酶阳性葡萄球菌、缓症链球菌、凝固酶阴性葡萄球菌属、溶血葡萄球菌、牛链球菌、大肠杆菌，药敏试验显示这些病原体对β-内酰胺类、头孢菌素类、糖肽类、甲氧苄啶-磺胺甲恶唑、利福平、喹诺酮类、林可酰胺类、恶唑烷酮类敏感，因此根据药敏试验制定了具体的治疗方案。
感染性心内膜炎是一种严重的疾病，也会影响儿童，在某些情况下会导致死亡。诊断性影像学检查和早期血培养对于及时干预具有重要意义。治疗必须具有针对性并尽快应用。
