Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Curr Biol. 2013 May 20;23(10):R456-9. doi: 10.1016/j.cub.2013.04.033.
Genetic evidence on the role of specific histone amino acids or their posttranslational modifications in metazoan development has been lacking. A recent study reports that fruit flies carrying histone H3 lysine 27 (H3K27) mutations have the same homeotic gene expression and developmental defects as mutations in the enzyme that trimethylates H3K27.
在后生动物发育过程中，特定组蛋白氨基酸或其翻译后修饰的作用的遗传证据一直缺乏。最近的一项研究报告称，携带组蛋白 H3 赖氨酸 27（H3K27）突变的果蝇与三甲基化 H3K27 的酶突变具有相同的同源基因表达和发育缺陷。
