Department of Environmental Health Sciences, (Division of Physiology), The Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA; Departments of Physiology and of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, MD.
Auton Neurosci. 2013 Oct;177(2):181-93. doi: 10.1016/j.autneu.2013.04.010. Epub 2013 May 21.
This study aimed to dissect the roles played by the autonomic interoreceptors, the carotid bodies (cbs) and the aortic bodies (abs) on the vascular resistances of several organs in anesthetized, paralyzed, artificially ventilated cats challenged by systemic hypoxemia. Two 15 min challenges stimulated each of 5 animals in two different groups: (1) in the intact group hypoxic hypoxia (10% O2 in N2; HH) stimulated both abs and cbs, increasing neural output to the nucleus tractus solitarius (NTS); (2) in this group carbon monoxide hypoxia (30% O2 in N2 with the addition of CO; COH) stimulated only the abs, increasing neural output to the NTS. (3) In the second group in which their bilateral aortic depressor nerves had been transected only the cbs increased neural output to the NTS during the HH challenge; (4) in this aortic body resected group during COH neither abs nor cbs increased neural traffic to the NTS. CO and 10% O2 reduced Hb saturation to the same level. With the use of radiolabeled microspheres blood flow was measured in a variety of organs. Organ vascular resistance was calculated by dividing the aortic pressure by that organ's blood flow. The spleen and pancreas revealed a vasoconstriction in the face of systemic hypoxemia, thought to be sympathetic nervous system (SNS)-mediated. The adrenals and the eyes vasodilated only when cbs were stimulated. Vasodilation in the heart and diaphragm showed no effect of chemoreceptor stimulated increase in SNS output. Different chemoreceptor involvement had different effects on the organs.
本研究旨在剖析自主内感受器、颈动脉体（CBS）和主动脉体（ABS）在麻醉、麻痹、人工通气的猫全身缺氧时对多个器官血管阻力的作用。通过 5 只动物的 2 个不同组进行了 2 次 15 分钟的挑战：（1）在完整组中，缺氧性缺氧（N2 中的 10%O2；HH）刺激了 ABS 和 CBS，增加了向孤束核（NTS）的神经输出；（2）在该组中，一氧化碳缺氧（N2 中的 30%O2 加上 CO；COH）仅刺激 ABS，增加了向 NTS 的神经输出。（3）在第二组中，双侧主动脉减压神经已被切断，只有 CBS 在 HH 挑战期间增加了向 NTS 的神经输出；（4）在主动脉体切除组中，COH 期间 ABS 和 CBS 均未增加向 NTS 的神经流量。CO 和 10%O2 将 Hb 饱和度降低到相同水平。使用放射性标记的微球测量了各种器官的血流量。通过将主动脉压除以该器官的血流量来计算器官血管阻力。在面对全身缺氧时，脾脏和胰腺显示出血管收缩，这被认为是交感神经系统（SNS）介导的。只有在刺激 CBS 时，肾上腺和眼睛才会扩张。心脏和横膈膜的血管扩张不受化学感受器刺激 SNS 输出增加的影响。不同的化学感受器参与对器官有不同的影响。
