Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden.
Neurotoxicology. 2013 Jul;37:190-6. doi: 10.1016/j.neuro.2013.05.007. Epub 2013 May 20.
Perfluorohexane sulfonate (PFHxS) is an industrial chemical and belongs to the group of perfluorinated compounds (PFCs). It has recently been shown to cause developmental neurobehavioral defects in mammals. These compounds are commonly used in products such as surfactant and protective coating due to their ability to repel water- and oil stains. PFCs are globally found in the environment as well as in human umbilical cord blood, serum and breast milk. In a previous study on other well-known PFCs, i.e. PFOS and PFOA, it was shown that neonatal exposure caused altered neuroprotein levels in the hippocampus and cerebral cortex in neonatal male mice. The present study show that neonatal exposure to PFHxS, during the peak of the brain growth spurt, can alter neuroprotein levels, e.g. CaMKII, GAP-43, synaptophysin and tau, which are essential for normal brain development in mice. This was measured for both males and females, in hippocampus and cerebral cortex. The results suggest that PFHxS may act as a developmental neurotoxicant and the effects are similar to that of PFOS and PFOA, but also to other substances such as PCBs, PBDEs and bisphenol A.
全氟己烷磺酸（PFHxS）是一种工业化学品，属于全氟化合物（PFCs）的一类。最近的研究表明，它会导致哺乳动物发育性神经行为缺陷。这些化合物因其能够排斥水和油斑而常用于表面活性剂和防护涂层等产品中。PFCs 在环境中以及人类脐带血、血清和母乳中都有发现。在之前对其他知名 PFCs（如 PFOS 和 PFOA）的研究中，研究表明新生期暴露会导致新生雄性小鼠海马体和大脑皮层中的神经蛋白水平发生改变。本研究表明，在大脑生长突增高峰期新生期接触 PFHxS 会改变神经蛋白水平，例如 CaMKII、GAP-43、突触素和 tau，这些蛋白对于正常的大脑发育是必不可少的。这在雄性和雌性小鼠的海马体和大脑皮层中都有测量。研究结果表明，PFHxS 可能具有发育神经毒性作用，其影响类似于 PFOS 和 PFOA，但也类似于其他物质，如多氯联苯、PBDE 和双酚 A。
