化学蛋白质组学驱动的橄榄苦苷作为 Hsp90 抑制剂的发现。
Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.
机构信息
Dipartimento di Farmacia, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy.
出版信息
Chem Commun (Camb). 2013 Jul 4;49(52):5844-6. doi: 10.1039/c3cc41858h. Epub 2013 May 24.
PMID:23703283
Abstract
Hsp90, a key target in cancer therapy, has been identified as the main partner of oleocanthal, an olive oil bioactive compound. A combination of chemical and biological assays disclosed its mechanism of action at the molecular level.
摘要
Hsp90，癌症治疗的关键靶点，被鉴定为橄榄油生物活性化合物油酸醇的主要伴侣。化学和生物测定的组合揭示了其在分子水平上的作用机制。
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