Schulert Grant S, Walsh William F, Weitkamp Jörn-Hendrik
Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.
AJP Rep. 2011 Dec;1(2):105-10. doi: 10.1055/s-0031-1285984. Epub 2011 Aug 2.
Fetal parvovirus B19 infection causes anemia, hydrops, and pregnancy loss but is generally not considered teratogenic. Nevertheless, disturbances of neuronal migration have been described with congenital parvovirus infection. We evaluated a term infant with congenital parvovirus disease and polymicrogyria. We compared this case with four other reports of central nervous system disease after birth to parvovirus-infected mothers. After an extensive diagnostic evaluation, this infant was found to have congenital parvovirus disease with severe anemia and nonimmune hydrops as well as extensive polymicrogyria. Although rare, this report and literature review suggest that parvovirus B19 has the potential to disrupt normal neurodevelopment. We suggest that infants with severe congenital parvovirus infection have close developmental surveillance and if symptomatic undergo neuroimaging to assess for disorders of neuromigration.
胎儿细小病毒B19感染可导致贫血、水肿和流产，但一般不被认为具有致畸性。然而，已有先天性细小病毒感染导致神经元迁移障碍的相关描述。我们评估了一名患有先天性细小病毒病和多小脑回畸形的足月儿。我们将该病例与另外四例母亲感染细小病毒后出生的中枢神经系统疾病报告进行了比较。经过广泛的诊断评估，发现这名婴儿患有先天性细小病毒病，伴有严重贫血和非免疫性水肿以及广泛的多小脑回畸形。尽管罕见，但本报告及文献综述表明，细小病毒B19有可能扰乱正常的神经发育。我们建议，患有严重先天性细小病毒感染的婴儿应进行密切的发育监测，如有症状应进行神经影像学检查以评估神经元迁移障碍。
