Disturbance of cerebral neuronal migration following congenital parvovirus B19 infection.

作者信息

Pistorius Lourens Rasmus, Smal Jaime, de Haan Timo Robert, Page-Christiaens Godelieve C M L, Verboon-Maciolek Malgorzata, Oepkes Dick, de Vries Linda S

机构信息

Department of Obstetrics, University Medical Center Utrecht, Utrecht, The Netherlands.

出版信息

Fetal Diagn Ther. 2008;24(4):491-4. doi: 10.1159/000180119. Epub 2008 Dec 5.

OBJECTIVE

We describe the clinical course of an infant who presented with severe fetal anemia and fetal hydrops following congenital parvovirus B19 infection before 16 gestational weeks. The fetus was treated by cordocentesis and intrauterine transfusion at 18 weeks.

RESULTS

The infant demonstrated mild unilateral ventriculomegaly on antenatal magnetic resonance imaging, and polymicrogyria and heterotopia on postnatal magnetic resonance imaging.

CONCLUSION

This adds to the evidence in recent literature of central nervous system damage associated with congenital parvovirus B19 infection.