Saito Yoshiaki, Matsuda Yuko, Sugai Kenji, Nakagawa Eiji, Ishiyama Akihiko, Saito Takashi, Komaki Hiforumi, Sasaki Masayuki, Miyata Akiko
Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
Brain Dev. 2014 Apr;36(4):337-41. doi: 10.1016/j.braindev.2013.04.014. Epub 2013 May 23.
A 5-year-old girl exhibited daily episodes of repetitive blinking lasting 5-10 s. Electroencephalography (EEG) revealed marked photoparoxysmal responses (PPR) at 3-20 Hz of photic stimulation and diffuse spike-wave bursts during sleep. A 24-h video EEG identified 11 episodes of repetitive blinking, 3 of which resulted in widespread spike-wave discharges. These suggested that the behavior of the patient represented self-induction of PPR. Valproate sodium was ineffective in decreasing PPR, as revealed by EEG, and the frequency of blinking episodes, but clonazepam attenuated PPR and significantly decreased the blinking behavior.
