Ekstrom K E, Benevenga N J, Grummer R H
J Nutr. 1975 Jul;105(7):851-60. doi: 10.1093/jn/105.7.851.
Two studies were conducted to establish the effects of dietary lactose supplied from dried whey on the lactase activity in the contents of the small intestine and cecum as well as the mucosa of the small intestine. In the first study, feeding 0, 10, 25, or 40% dried whey for 120 days did not alter the mucosal lactase specific activity (mumoles galactose released/mg protein) in the duodenum, upper jejunum, or lower ileum. In the second study, total lactase activity in the small intestine was estimated from the total activity found in 10-cm segments of each meter of small intestine. Feeding a diet containing 40% whey continuously from weaning at 5 weeks of age or from 12 weeks of age did not alter the total lactase activity of pigs killed at 21 weeks of age. Dietary lactose tended to increase the lactase activity in the contents of the cecum and small intestine, but the increases were not always statistically significant. In the second study, Chester White pigs had approximately threefold greater mucosal lactase activities than that of Hampshires. These two breeds may be suitable models for detailed studies into the relationships between lactase deficiency and lactose intolerance.
进行了两项研究，以确定由干乳清提供的膳食乳糖对小肠和盲肠内容物以及小肠黏膜中乳糖酶活性的影响。在第一项研究中，喂食0%、10%、25%或40%的干乳清120天，并未改变十二指肠、空肠上段或回肠下段黏膜乳糖酶的比活性（每毫克蛋白质释放的半乳糖微摩尔数）。在第二项研究中，从小肠每米的10厘米段中发现的总活性来估算小肠中的总乳糖酶活性。从5周龄断奶时或12周龄开始持续喂食含40%乳清的日粮，并未改变21周龄时宰杀的猪的总乳糖酶活性。膳食乳糖倾向于增加盲肠和小肠内容物中的乳糖酶活性，但增加并不总是具有统计学意义。在第二项研究中，切斯特白猪的黏膜乳糖酶活性大约是汉普夏猪的三倍。这两个品种可能是深入研究乳糖酶缺乏与乳糖不耐受之间关系的合适模型。
