双时间点2-脱氧-2-[18F]氟-D-葡萄糖PET/CT：局部晚期乳腺癌的淋巴结分期
Dual time point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: nodal staging in locally advanced breast cancer.
作者信息
García Vicente A M, Soriano Castrejón A, Cruz Mora M Á, Ortega Ruiperez C, Espinosa Aunión R, León Martín A, González Ageitos A, Van Gómez López O
机构信息
Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain.
Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain.
出版信息
Rev Esp Med Nucl Imagen Mol. 2014 Jan-Feb;33(1):1-5. doi: 10.1016/j.remn.2013.03.005. Epub 2013 May 23.
AIM
To assess dual time point 2-deoxy-2-[(18)F]fluoro-D-glucose (18)(F)FDG PET-CT accuracy in nodal staging and in detection of extra-axillary involvement.
MATERIAL AND METHODS
Dual time point [(18)F] FDG PET/CT scan was performed in 75 patients. Visual and semiquantitative assessment of lymph nodes was performed. Semiquantitative measurement of SUV and ROC-analysis were carried out to calculate SUV(max) cut-off value with the best diagnostic performance. Axillary and extra-axillary lymph node chains were evaluated.
RESULTS
Sensitivity and specificity of visual assessment was 87.3% and 75%, respectively. SUV(max) values with the best sensitivity were 0.90 and 0.95 for early and delayed PET, respectively. SUV(max) values with the best specificity were 1.95 and 2.75, respectively. Extra-axillary lymph node involvement was detected in 26.7%.
CONCLUSION
FDG PET/CT detected extra-axillary lymph node involvement in one-fourth of the patients. Semiquantitative lymph node analysis did not show any advantage over the visual evaluation.
目的
评估双时间点2-脱氧-2-[(18)F]氟-D-葡萄糖（18）F-FDG PET-CT在淋巴结分期及检测腋窝外受累情况方面的准确性。
材料与方法
对75例患者进行双时间点[(18)F] FDG PET/CT扫描。对淋巴结进行视觉和半定量评估。进行SUV的半定量测量及ROC分析，以计算具有最佳诊断性能的SUV（最大值）临界值。评估腋窝及腋窝外淋巴结链。
结果
视觉评估的敏感性和特异性分别为87.3%和75%。早期和延迟PET具有最佳敏感性的SUV（最大值）分别为0.90和0.95。具有最佳特异性的SUV（最大值）分别为1.95和2.75。检测到26.7%的患者有腋窝外淋巴结受累。
结论
FDG PET/CT在四分之一的患者中检测到腋窝外淋巴结受累。半定量淋巴结分析与视觉评估相比未显示出任何优势。
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