Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Steroids. 2013 Aug;78(8):767-72. doi: 10.1016/j.steroids.2013.05.005. Epub 2013 May 21.
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. There are multiple ways to induce ovulation in PCOS patients, which will eventually provide a successful live birth. Each of these treatments varies in aggressiveness and effectiveness. Ranging from lifestyle modifications, through insulin-sensitizing agents, selective estrogen receptor modulators, aromatase inhibitors, gonadotropins, to laparoscopic ovarian drilling and assisted reproductive techniques, each method achieves ovulation induction through different mechanisms of action. This review provides a description and specific characteristics of the different methods used for ovulation induction which can help to design a personalized approach to each PCOS patient, and a general stepwise approach to ovulation induction in these patients.
多囊卵巢综合征(PCOS)是排卵障碍性不孕的最常见原因。有多种方法可诱导 PCOS 患者排卵,最终可实现成功活产。这些治疗方法在侵袭性和有效性方面存在差异。从生活方式的改变,到胰岛素增敏剂、选择性雌激素受体调节剂、芳香化酶抑制剂、促性腺激素,再到腹腔镜卵巢打孔术和辅助生殖技术,每种方法通过不同的作用机制实现排卵诱导。本文综述了不同的排卵诱导方法,并详细描述了它们各自的特点,有助于为每位 PCOS 患者设计个性化的方法,以及为这些患者制定一般性的排卵诱导步骤。