Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Int J Pharm. 2013 Aug 16;452(1-2):211-9. doi: 10.1016/j.ijpharm.2013.05.001. Epub 2013 May 22.
Embolic agents, such as microparticles, microspheres or beads used in current embolotherapy are mostly radiolucent, which means the agents are invisible under X-ray imaging during and after the process of embolization, and the fate of these particles cannot be precisely assessed. In this research, a radiopaque embolic agent was developed by encapsulating lipiodol in polyvinyl alcohol. The lipiodol-containing polyvinyl alcohol microcapsules (LPMs) were characterized and evaluated for their morphology, size distribution, lipiodol content, lipiodol release, elasticity, and deliverability through catheter. The radiopacity of LPMs in vials and in living mice was both detected by an X-ray imaging system. The biocompatibility of LPMs was investigated with L929 cells and in mice after subcutaneous injection. Embolization of LPMs to a rabbit kidney was performed under digital subtraction angiography (DSA) and the radiopacity of LPMs was verified by computed tomography (CT).
栓塞剂，如微球或微珠，目前用于栓塞疗法，主要是不透射线的，这意味着这些剂在栓塞过程中和栓塞后在 X 射线成像下是不可见的，并且这些颗粒的命运无法精确评估。在这项研究中，通过将碘油包封在聚乙烯醇中开发了一种不透射线的栓塞剂。对含碘油的聚乙烯醇微囊（LPMs）进行了表征和评估，包括形态、粒径分布、碘油含量、碘油释放、弹性和通过导管的输送能力。通过 X 射线成像系统检测了 LPMs 小瓶中和活鼠体内的放射密度。通过 L929 细胞和皮下注射小鼠研究了 LPMs 的生物相容性。在数字减影血管造影（DSA）下对兔肾进行了 LPMs 栓塞，并通过计算机断层扫描（CT）验证了 LPMs 的放射密度。
