Attwood D, Udeala O K
J Pharm Pharmacol. 1975 Jun;27(6):395-9. doi: 10.1111/j.2042-7158.1975.tb09467.x.
The effect of sodium chloride on the micellar properties of the antihistamines, dephenhydramine hydrochloride, bromodiphenhydramine hydrochloride, chlorcyclizine hydrochloride and diphenylpyraline hydrochloride in aqueous solution has been investigated by light scattering and viscometric methods. The drugs behaved as typical ionic surfactants showing an increase in aggregation number and decrease in critical micelle concentration as the electrolyte concentration was increased over the range 0.05 to 0.154 mol kg-minus1. A linear relation between log critical micelle concentration and log counterion concentration was established, from which values of the degree of ionization and the free energy of micellization were calculated. The intrinsic viscosity was decreased by the addition of electrolyte and this has been attributed to a decrease in micellar hydration due to a removal of hydrogen-bonded water.
通过光散射和粘度测定法研究了氯化钠对水溶液中抗组胺药盐酸苯海拉明、盐酸溴苯海拉明、盐酸氯环利嗪和盐酸二苯拉林胶束性质的影响。这些药物表现为典型的离子表面活性剂，在0.05至0.154 mol kg⁻¹的电解质浓度范围内，随着电解质浓度的增加，聚集数增加，临界胶束浓度降低。建立了log临界胶束浓度与log抗衡离子浓度之间的线性关系，并据此计算了电离度和胶束化自由能的值。添加电解质会降低特性粘度，这归因于氢键结合水的去除导致胶束水合作用的降低。
