Kostopoulos G K, Yarbrough G G
J Pharm Pharmacol. 1975 Jun;27(6):408-12. doi: 10.1111/j.2042-7158.1975.tb09469.x.
The effects of microiontophoretic applications of equivalent doses (ejection times and currents) of noradrenaline, amphetamine, octopamine and p-hydroxynorephedrine on the spontaneous firing of Purkinje and unidentified cells in the cerebellum of rats were examined. In addition, the effects of amphetamine of Purkinje cells were examined in animals pretreated with the tyrosine hydroxylase inhibitor, alpha-methyltyrosine (alpha-MpT) or with a combination of reserpine plus alpha-MpT. The results indicate that the "false transmitters" are weak agonists when compared to noradrenaline in inhibiting the firing of Purkinje cells. The results of the iontophoretic studies with amphetamine are not consistent with a pre-synaptic releasing effect by amphetamine at noradrenergic synapses in the cns since the efficacy of amphetamine on Purkinje cells was unaltered after pretreatment with alpha-MpT or alpha-MpT plus reserpine.
研究了微离子电渗法施加等效剂量（喷射时间和电流）的去甲肾上腺素、苯丙胺、章鱼胺和对羟基去甲麻黄碱对大鼠小脑浦肯野细胞和未鉴定细胞自发放电的影响。此外，还研究了在用酪氨酸羟化酶抑制剂α-甲基酪氨酸（α-MpT）或利血平加α-MpT预处理的动物中，苯丙胺对浦肯野细胞的影响。结果表明，与去甲肾上腺素相比，“假递质”在抑制浦肯野细胞放电方面是弱激动剂。苯丙胺离子电渗研究的结果与苯丙胺在中枢神经系统去甲肾上腺素能突触处的突触前释放作用不一致，因为在用α-MpT或α-MpT加利血平预处理后，苯丙胺对浦肯野细胞的作用未改变。
