Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Mediators Inflamm. 2013;2013:479739. doi: 10.1155/2013/479739. Epub 2013 Apr 18.
The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues, including the pituitary. The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland in vivo (rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and in vitro (adenopituitary cell cultures treated with the adipokine). Here, by a combination of in vivo and in vitro experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism.
脂联素抵抗素是一种胰岛素拮抗因子，在炎症、免疫、食物摄入和性腺功能中发挥调节作用，也调节大鼠腺垂体细胞培养物中的生长激素 (GH) 分泌。虽然脂肪组织是抵抗素的主要来源，但它也在其他组织中表达，包括垂体。本研究旨在研究抵抗素在体内（处于不同营养状态的大鼠，用抵抗素进行急性和慢性处理）和体外（用脂联素处理腺垂体细胞培养物）对垂体脂质代谢的可能作用。在这里，我们通过体内和体外实验模型的结合，证明了中枢急性和慢性给予抵抗素可增强参与脂肪分解的脂质代谢酶的 mRNA 水平，并且抑制参与脂肪生成的脂质代谢酶的 mRNA 水平。总之，我们的结果首次证明抵抗素对垂体的脂质代谢具有调节作用，为这种脂肪因子如何参与脂质代谢的综合控制提供了新的见解。
