Lindner Jasmin, Meissner Kamila Anna, Schettert Isolmar, Wrenger Carsten
Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of São Paulo, Avenida Prof. Lineu Prestes 1374, 05508-000 São Paulo, SP, Brazil.
Int J Cell Biol. 2013;2013:435981. doi: 10.1155/2013/435981. Epub 2013 Apr 28.
Malaria is an infectious disease that results in serious health problems in the countries in which it is endemic. Annually this parasitic disease leads to more than half a million deaths; most of these are children in Africa. An effective vaccine is not available, and the treatment of the disease is solely dependent on chemotherapy. However, drug resistance is spreading, and the identification of new drug targets as well as the development of new antimalarials is urgently required. Attention has been drawn to a variety of essential plasmodial proteins, which are targeted to intra- or extracellular destinations, such as the digestive vacuole, the apicoplast, or into the host cell. Interfering with the action or the transport of these proteins will impede proliferation of the parasite. In this mini review, we will shed light on the present discovery of chemotherapeutics and potential drug targets involved in protein trafficking processes in the malaria parasite.
疟疾是一种传染病，在其流行的国家会导致严重的健康问题。每年这种寄生虫病导致超过50万人死亡；其中大多数是非洲儿童。目前尚无有效的疫苗，该病的治疗完全依赖化疗。然而，耐药性正在蔓延，迫切需要确定新的药物靶点并开发新的抗疟药物。人们已将注意力投向多种必需的疟原虫蛋白，这些蛋白被靶向到细胞内或细胞外的目的地，如消化液泡、质体或宿主细胞。干扰这些蛋白的作用或运输将阻碍寄生虫的增殖。在这篇小型综述中，我们将阐明目前在疟原虫蛋白质运输过程中涉及的化疗药物和潜在药物靶点的发现。
