Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London SW7 2AZ, UK.
J Diabetes Res. 2013;2013:906590. doi: 10.1155/2013/906590. Epub 2013 Apr 11.
More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models. We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.
全基因组关联研究（GWAS）表明，超过 65 个基因座编码多达 500 种不同的基因，这些基因座与 2 型糖尿病（T2D）的发病风险增加有关。虽然过去的小鼠模型是理解 T2D 更强效风险基因（例如导致新生儿或青少年发病的成年型糖尿病的基因）的机制的核心，但迄今为止，只有少数通过 GWAS 鉴定的基因，特别是 TCF7L2 和 ZnT8/SLC30A8，在小鼠模型中进行了研究。在这里，我们讨论了用于研究后两个基因的动物模型，并为未来通过高通量方法更有效地挖掘人类遗传学提供的信息提供了展望。
